| 摘要: |
| 目的 探讨重度颅脑损伤后丙戊酸钠预防癫痫发作的疗效.方法 76例重度颅脑损伤患者,随机分成对照组（35例）和治疗组（41例）,在常规治疗方案相同的情况下,治疗组给予丙戊酸钠预防癫痫发作,先静脉给药3d,改口服丙戊酸钠4～10周;对比两组病例伤后（2个月~2年）癫痫的发生率.结果 对照组癫痫发作13例（37.1%）,其中,8例早期癫痫发作,5例晚期发作;治疗组癫痫发作3例（7.3%）,其中,2例早期癫痫发作,1例晚期发作,两者差异有统计学意义（P〈0.05,P〈0.01）.结论 丙戊酸钠的早期应用对预防和控制颅脑损伤后癫痫发作安全、有效、可行. |
| 关键词: 重度颅脑损伤 癫痫 丙戊酸钠 |
| DOI： |
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| Clinical research onvalproic acid sodium preventing epilepsy after severe craniocerebral injury |
| FANG Jun |
| () |
| Abstract: |
| Objeetlve ＂To investigate the curative effect of valproic acid sodium on preventing the occurrence of epilepsy after severe craniocerebral injury. Methods 76 cases of patients suffered from severe craniocerebral injury, were randomly divided into control group （n = 35） and treatment group （n = 41 ）. Patients in thetreatment group were given sodium valproie acid （intravenous for 3 days at first, then take orally for 4 - 10 weeks） to prevent epilepsy on the basis of conventional treatment. Compare the incidence of epilepsy of the two group,s （2 months to 2 years after injury）. Results 13cases （37.1% ） of epilepsy occurred in control group, and 8 of them were early epileptic attack, 5 were late epileptic attack. 3cases （7.3%） in epilepsy treatment group were epileptic attack, 2 of them were early epileptic attack, one lateepileptic attack, the differeneesof incidence between the two groups were statistically significant （P 〈 0. 05）. Conclusions Early application of valproate for preventing and control the occurrence of epilepsy after craniocerebral injury is safe, effective and feasible. |
| Key words: Severe craniocerebral injury Epilepsy Valproic acid sodium |
