| 摘要: |
| 目的 探讨血清铁蛋白（serum ferritin,SF）在多发性骨髓瘤（multiple myeloma,MM）患者中的变化及临床意义.方法 选择30例多发性骨髓瘤患者（MM组）和30名健康志愿者（对照组）作为研究对象,检测其SF、血清β2-微球蛋白（β2-microglobulin,β2-MG）和乳酸脱氢酶（lactate dehydrogenase,LDH）的水平,并对检测结果和阳性检出率进行统计分析.结果 MM组的SF水平（613.6±274.6μg/L）明显高于对照组（131.8±59.0μg/L）,差异具有统计学意义（P〈0.01）.MM组SF与血清β2-MG水平呈明显正相关（r=0.545,P〈0.01）;而与血清LDH水平无明显相关（r=0.349,P〉0.05）.MM组患者SF的阳性检出率与血清β2-MG之间没有显著性差异（χ2=1.071,P〉0.05）;而SF的阳性检出率明显高于血清LDH,差异具有统计学意义（χ2=18.373,P〈0.01）.结论 多发性骨髓瘤患者SF水平明显升高; SF和血清β2-MG水平呈明显正相关,且二者阳性检出率相近.SF对多发性骨髓瘤的辅助诊断有一定参考价值. |
| 关键词: 多发性骨髓瘤 血清铁蛋白 β2-微球蛋白 乳酸脱氢酶 化学发光免疫法 |
| DOI： |
|
| 基金项目: |
|
| Detect serumferritin levels for patients suffered from multiple myeloma and clinical significance |
|
| () |
| Abstract: |
| Objective To discuss the clinical significance of serum ferritin（SF） in patients suffered from multiple myeloma （ MM ）. Methods Detectthe levels of SF, β2- microglobulin （ β2- MG） and lactate dehydrogenase（LDH） in serumfor 30 patients with MM and 30 healthy volunteersrespectively. The data was analyzed by IBM SPSS Statistics. Results The SFlevels in patients with MM （613.6 ± 274.6μg/L） were significantly higher than those in normal controls （131. 8 ±59. 0μg/L） （P 〈 0. 01 ）. SF levels positively correlated to β2- MG levels in MM group （ r = 0. 545, P 〈 0. 01 ）, but the positive rates were close with each other （X2 = 1. 071, P 〉 0.05 ）. The relationship between SF and LDH levels present no statistically significant （r =0. 349, P 〉0. 05）, but the positive rates are statistically different （X2 = 18. 373 ,P 〈 0. 01 ）. Conclusions The SFlevels were increased in patients with MM. SF levels positively correlated to β2 - MG levels, and the positive rates were close to each other. SF might be used as a assistant diagnosis for diagnosing multiple myeloma. |
| Key words: Multiple myeloma Serum Ferritin β2- microglobulin Lactate dehydrogenase Chemil lmmunoassay |
